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CD248 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-CD248-Antikörper wurde für WB, IHC (p) und IF validiert. Er ist geeignet, CD248 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN500885

Kurzübersicht für CD248 Antikörper (C-Term) (ABIN500885)

Target

Alle CD248 Antikörper anzeigen
CD248 (CD248 Molecule, Endosialin (CD248))

Reaktivität

  • 46
  • 32
  • 10
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 37
  • 9
  • 1
  • 1
Kaninchen

Klonalität

  • 39
  • 9
Polyklonal

Konjugat

  • 30
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD248 Antikörper ist unkonjugiert

Applikation

  • 43
  • 24
  • 18
  • 13
  • 13
  • 8
  • 6
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
  • Bindungsspezifität

    • 16
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects CD248 / TEM1 at C-term. It recognizes both isoforms.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, Mouse, Rat

    Aufreinigung

    Peptide affinity chromatography

    Immunogen

    TEM1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human TEM1.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western blot. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS, 0.02 % Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    CD248 (CD248 Molecule, Endosialin (CD248))

    Andere Bezeichnung

    CD248 / TEM1

    Hintergrund

    Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion. At least two isoforms of TEM1 are known to exist.Synonyms: CD164L1, Endosialin, Tumor endothelial marker 1

    Gen-ID

    57124

    NCBI Accession

    NP_065137
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