SRPX Antikörper (N-Term)

Produktnummer ABIN500807

Produktdetails anti-SRPX Antikörper

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRPX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: SRPX1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human SRPX1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.25 - 0.5 μg/mL. Immunhistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu SRPX

Target: SRPX (Sushi-Repeat Containing Protein, X-Linked (SRPX))

Andere Bezeichnung: SRPX / ETX1 (SRPX Produkte)

Synonyme: DRS antikoerper, ETX1 antikoerper, SRPX1 antikoerper, drs antikoerper, drs-1 antikoerper, drs-2 antikoerper, mDRS-1 antikoerper, mDRS-2 antikoerper, Drs antikoerper, sushi repeat containing protein, X-linked antikoerper, sushi-repeat-containing protein antikoerper, sushi-repeat-containing protein, X-linked antikoerper, SRPX antikoerper, Srpx antikoerper

Hintergrund: SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.Synonyms: Sushi repeat-containing protein SRPX

Gen-ID: 8406

NCBI Accession: NP_006298