SIRT2 Antikörper (N-Term)

Produktnummer ABIN500726

Der Kaninchen Polyklonal Anti-SIRT2-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, SIRT2 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für SIRT2 Antikörper (N-Term) (ABIN500726)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-SIRT2 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects SIRT2 / SIR2 at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromtography

Immunogen: SIRT2 antibody was raised against a 17 amino acid peptide near the amino terminus of the human SIRT2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2.5 - 5 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Andere Bezeichnung: SIRT2 / SIR2

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjugate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been suggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.Synonyms: NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT-2, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), sirtuin 2, sirtuin type 2, sirtuin-2

Gen-ID: 22933

NCBI Accession: NP_036369

UniProt: Q8IXJ6