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SIGIRR Antikörper (C-Term)

SIGIRR Reaktivität: Human, Maus WB, EIA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500712
  • Target Alle SIGIRR Antikörper anzeigen
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Bindungsspezifität
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    C-Term
    Reaktivität
    • 22
    • 12
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 25
    • 4
    • 1
    Kaninchen
    Klonalität
    • 25
    • 5
    Polyklonal
    Konjugat
    • 22
    • 6
    • 2
    Dieser SIGIRR Antikörper ist unkonjugiert
    Applikation
    • 28
    • 14
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)
    Spezifität
    This antibody detects SIGIRR / TIR8 at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of mouse SIGIRR.
    Isotyp
    IgG
    Top Product
    Discover our top product SIGIRR Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 0.5 to 1 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Andere Bezeichnung
    SIGIRR / TIR8 (SIGIRR Produkte)
    Synonyme
    TIR8 antikoerper, AI256711 antikoerper, sc:d148 antikoerper, RGD1306732 antikoerper, single Ig and TIR domain containing antikoerper, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antikoerper, SIGIRR antikoerper, Sigirr antikoerper, sigirr antikoerper
    Hintergrund
    SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family (3). Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling (4,5). However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion (4).Synonyms: Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, UNQ301/PRO342
    Gen-ID
    59307
    UniProt
    Q6IA17
    Pathways
    Toll-Like Receptors Cascades
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