MLC1 Antikörper (AA 321-377) (AbBy Fluor® 680)

Produktnummer ABIN5006907

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MLC1 in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für MLC1 Antikörper (AA 321-377) (AbBy Fluor® 680) (ABIN5006907)

Target: MLC1

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLC1 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-MLC1 Antikörper (AbBy Fluor® 680)

Bindungsspezifität: AA 321-377

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MLC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MLC1

Target: MLC1

Hintergrund:

Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

Gen-ID: 23209

UniProt: Q15049