FBXL20 Antikörper (C-Term)

Produktnummer ABIN500690

Der Kaninchen Polyklonal Anti-FBXL20-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, FBXL20 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für FBXL20 Antikörper (C-Term) (ABIN500690)

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXL20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-FBXL20 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects FBXL20 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: FBXL20 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human FBXL20.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu FBXL20

Target: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Andere Bezeichnung: FBXL20

Hintergrund: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.Synonyms: F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like, F-box/LRR-repeat protein 20, FBL2

Gen-ID: 84961

NCBI Accession: NP_116264

UniProt: Q96IG2