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MHC, Class I Antikörper (AA 81-180) (AbBy Fluor® 680)

Dieses Anti-MHC, Class I-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MHC, Class I in WB, IF (cc) und IF (p). Geeignet für Human.
Produktnummer ABIN5006834

Kurzübersicht für MHC, Class I Antikörper (AA 81-180) (AbBy Fluor® 680) (ABIN5006834)

Target

Alle MHC, Class I Antikörper anzeigen
MHC, Class I

Reaktivität

  • 70
  • 45
  • 13
  • 9
  • 7
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 1
Human

Wirt

  • 65
  • 46
  • 7
  • 1
Kaninchen

Klonalität

  • 81
  • 35
  • 3
Polyklonal

Konjugat

  • 38
  • 15
  • 12
  • 9
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MHC, Class I Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 76
  • 54
  • 34
  • 25
  • 21
  • 14
  • 13
  • 13
  • 12
  • 11
  • 7
  • 5
  • 5
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 18
    • 16
    AA 81-180

    Kreuzreaktivität

    Human

    Homologie

    Mouse,Rat

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MHC class I

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MHC, Class I

    Andere Bezeichnung

    MHC class 1

    Hintergrund

    Synonyms: A 28, A 9, Aw 24, Aw 68, CLASS I HISTOCOMPATIBILITY ANTIGEN, H2 K1, H2K, HLA A, HLA-A, HLA C, HLA-C, HLA class I histocompatibility antigen A 1 alpha chain, HLA class I histocompatibility antigen A 11 alpha chain, HLA class I histocompatibility antigen A 2 alpha chain, HLA class I histocompatibility antigen A 24 alpha chain, HLA class I histocompatibility antigen A 3 alpha chain, HLA class I histocompatibility antigen A 30 alpha chain, HLA class I histocompatibility antigen A 32 alpha chain, HLA class I histocompatibility antigen A 68 alpha chain, HLAA, Major histocompatibility complex class I A, MHC class I heavy chain H2 K, 1C04_HUMAN.

    Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

    UniProt

    G0ZMJ8
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