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SATB1 Antikörper (C-Term)

Dieses Anti-SATB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SATB1 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN500670

Kurzübersicht für SATB1 Antikörper (C-Term) (ABIN500670)

Target

Alle SATB1 Antikörper anzeigen
SATB1 (SATB Homeobox 1 (SATB1))

Reaktivität

  • 69
  • 48
  • 29
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 59
  • 9
  • 1
Kaninchen

Klonalität

  • 50
  • 19
Polyklonal

Konjugat

  • 38
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SATB1 Antikörper ist unkonjugiert

Applikation

  • 35
  • 23
  • 14
  • 14
  • 13
  • 13
  • 11
  • 11
  • 10
  • 7
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 16
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects SATB1 at C-term.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, mouse, rat

    Aufreinigung

    Peptide affinity chromatography

    Immunogen

    SATB1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human SATB1.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western blot: 2 - 4 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target

    SATB1 (SATB Homeobox 1 (SATB1))

    Andere Bezeichnung

    SATB1

    Hintergrund

    Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a \'cage-like\' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a \'genome organizer\' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.Synonyms: DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1

    Gen-ID

    6304

    UniProt

    Q01826

    Pathways

    Caspase Kaskade in der Apoptose, Activated T Cell Proliferation
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