Manic Fringe Antikörper (AA 221-321) (AbBy Fluor® 750)

Produktnummer ABIN5006485

Der Kaninchen Polyklonal Anti-Manic Fringe-Antikörper wurde für FACS, IF (cc) und IF (p) validiert. Er ist geeignet, Manic Fringe in Proben von Maus zu detektieren.

Kurzübersicht für Manic Fringe Antikörper (AA 221-321) (AbBy Fluor® 750) (ABIN5006485)

Target: Manic Fringe (MFNG) (MFNG)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Manic Fringe Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Manic Fringe Antikörper (AbBy Fluor® 750)

Bindungsspezifität: AA 221-321

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep,Horse,Chimpanzee

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Manic Fringe/MFNG

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Manic Fringe

Target: Manic Fringe (MFNG) (MFNG)

Andere Bezeichnung: Manic Fringe/MFNG

Hintergrund:

Synonyms: 3-N-acetylglucosaminyltransferase manic fringe, Beta-1, Beta-1,3-N-acetylglucosaminyltransferase manic fringe, MFNG, MFNG_HUMAN, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.

Background: Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Radical fringe plays a key role in the development of the limb bud. Lunatic fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice.

Gen-ID: 4242

Pathways: Notch Signalweg