DDIT4 Antikörper (N-Term)

Produktnummer ABIN500644

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DDIT4 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für DDIT4 Antikörper (N-Term) (ABIN500644)

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDIT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-DDIT4 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects DDIT4 at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: RTP801 antibody was raised against a 14 amino acid peptide from near the amino terminus of human DDIT4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu DDIT4

Target: DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))

Andere Bezeichnung: DDIT4

Hintergrund: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.Synonyms: DDIT-4, DNA-damage-inducible transcript 4, Dig2, HIF-1 responsive protein, Protein regulated in development and DNA damage response 1, REDD-1, REDD1, RTP801

Gen-ID: 54541

NCBI Accession: NP_061931

UniProt: Q9NX09

Pathways: Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process