RIMS2 Antikörper (Center)

Produktnummer ABIN500608

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RIMS2 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für RIMS2 Antikörper (Center) (ABIN500608)

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIMS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-RIMS2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects Rim2. Rim2 is known to exist in multiple isoforms, this antibody should recognize most of them. It is predicted to have no cross-reactivity to other Rim proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: Rim2 antibody was raised against a 17 amino acid peptide near the center of the human Rim2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu RIMS2

Target: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Andere Bezeichnung: RIMS2

Hintergrund: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.Synonyms: KIAA0751, RAB3IP3, RIM 2, RIM2, Rab-3-interacting molecule 2, Rab-3-interacting protein 3, Regulating synaptic membrane exocytosis protein 2

Gen-ID: 9699

NCBI Accession: NP_001093587

UniProt: Q9UQ26

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis