RCAN2 Antikörper (Center)

Produktnummer ABIN500577

Dieser Anti-RCAN2-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von RCAN2 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für RCAN2 Antikörper (Center) (ABIN500577)

Target: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RCAN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-RCAN2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects Calcipressin-2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: RCAN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu RCAN2

Target: RCAN2 (Regulator of Calcineurin 2 (RCAN2))

Andere Bezeichnung: Calcipressin-2

Hintergrund: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.Synonyms: DSCR1L1, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, RCAN2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4, ZAKI4

Gen-ID: 53901

UniProt: Q9JHG2