Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ISR-beta Antikörper (AA 1001-1100) (AbBy Fluor® 680)

This anti-ISR-beta antibody (ABIN5005452) is a Rabbit Polyclonal antibody detecting ISR-beta in WB, FACS, IF (cc), IF (p). Suitable for Human, Rat.
Produktnummer ABIN5005452

Kurzübersicht für ISR-beta Antikörper (AA 1001-1100) (AbBy Fluor® 680) (ABIN5005452)

Target

Alle ISR-beta Antikörper anzeigen
ISR-beta (Insulin Receptor beta (ISR-beta))

Reaktivität

  • 77
  • 71
  • 57
  • 3
  • 3
  • 3
  • 3
Human, Ratte

Wirt

  • 75
  • 2
Kaninchen

Klonalität

  • 75
  • 2
Polyklonal

Konjugat

  • 11
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
Dieser ISR-beta Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 58
  • 47
  • 38
  • 38
  • 16
  • 10
  • 10
  • 6
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 16
    • 16
    • 15
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1100

    Kreuzreaktivität

    Human, Ratte

    Homologie

    Mouse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human IR beta

    Isotyp

    IgG
  • Applikationshinweise

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    ISR-beta (Insulin Receptor beta (ISR-beta))

    Andere Bezeichnung

    Insulin Receptor Beta

    Hintergrund

    Synonyms: CD 220, CD220, CD220 antigen, HHF 5, HHF5, HIR B, INSR, INSR, Insulin receptor, Insulin receptor subunit beta, IR, INSR_HUMAN.

    Background: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

    Gen-ID

    3643

    UniProt

    P06213
Sie sind hier:
Chat with us!