CBLN1 Antikörper (C-Term)

Produktnummer ABIN500535

Dieses Anti-CBLN1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CBLN1 in WB, IF und EIA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für CBLN1 Antikörper (C-Term) (ABIN500535)

Target: CBLN1 (Cerebellin 1 Precursor (CBLN1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CBLN1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects Precerebellin at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: Precerebellin antibody was raised against a 16 amino acid peptide from near the carboxy- terminus human precerebellin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 2 - 4 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu CBLN1

Target: CBLN1 (Cerebellin 1 Precursor (CBLN1))

Andere Bezeichnung: Cerebellin-1

Hintergrund: Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q (1). Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway (2), and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (3). The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus (4). Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated (5).Synonyms: CBLN1, Precerebellin

Gen-ID: 869

NCBI Accession: NP_004343

UniProt: P23435