PPPDE1 Antikörper (C-Term)

Produktnummer ABIN500519

Der Kaninchen Polyklonal Anti-PPPDE1-Antikörper wurde für WB und EIA validiert. Er ist geeignet, PPPDE1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PPPDE1 Antikörper (C-Term) (ABIN500519)

Target: PPPDE1 (PPPDE Peptidase Domain Containing 1 (PPPDE1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPPDE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PPPDE1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects PNAS4.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinty chromatography

Immunogen: PNAS4 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human PNAS4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PPPDE1

Target: PPPDE1 (PPPDE Peptidase Domain Containing 1 (PPPDE1))

Andere Bezeichnung: PPPDE1

Hintergrund: PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.Synonyms: C1orf121, CGI-146, FAM152A, PNAS-4, PNAS4, PPPDE peptidase domain-containing protein 1

Gen-ID: 51029

NCBI Accession: NP_057160

UniProt: Q9BSY9