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MTA2 Antikörper (AA 652-668)

MTA2 Reaktivität: Human, Maus, Ratte WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500495
  • Target Alle MTA2 Antikörper anzeigen
    MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
    Bindungsspezifität
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 652-668
    Reaktivität
    • 44
    • 31
    • 28
    • 10
    • 9
    • 9
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 43
    • 4
    Kaninchen
    Klonalität
    • 42
    • 5
    Polyklonal
    Konjugat
    • 33
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTA2 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 13
    • 10
    • 9
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MTA2.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    DEAE purified
    Immunogen
    PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID (6), which differ from the mouse sequence by one amino acid (7).
    Isotyp
    IgG
    Top Product
    Discover our top product MTA2 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 0.5 to 1 μg/mL, HeLa cell lysate can be used as positive control and a 75 kDaband can be detected. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))
    Andere Bezeichnung
    MTA2 (MTA2 Produkte)
    Synonyme
    MTA1L1 antikoerper, PID antikoerper, fd61b05 antikoerper, wu:fd61b05 antikoerper, wu:fi29g02 antikoerper, zgc:63487 antikoerper, pid antikoerper, mta1l1 antikoerper, MTA2 antikoerper, DKFZp470E0911 antikoerper, AW550797 antikoerper, Mata1l1 antikoerper, Mta1l1 antikoerper, mmta2 antikoerper, metastasis associated 1 family member 2 antikoerper, metastasis associated 1 family, member 2 antikoerper, metastasis-associated gene family, member 2 antikoerper, metastasis associated 1 family member 2 L homeolog antikoerper, MTA2 antikoerper, mta2 antikoerper, Mta2 antikoerper, mta2.L antikoerper
    Hintergrund
    The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6-8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex
    Gen-ID
    9219
    UniProt
    O94776
    Pathways
    Chromatin Binding
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