PHAP1 Antikörper (C-Term)

Produktnummer ABIN500481

Produktdetails anti-PHAP1 Antikörper

Target: PHAP1 (ANP32A) (Acidic (Leucine-Rich) Nuclear phosphoprotein 32 Family, Member A (ANP32A))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects ANP32A at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: PHAP antibody was raised with a synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PHAP1

Target: PHAP1 (ANP32A) (Acidic (Leucine-Rich) Nuclear phosphoprotein 32 Family, Member A (ANP32A))

Andere Bezeichnung: ANP32A (ANP32A Produkte)

Synonyme: C15orf1 antikoerper, HPPCn antikoerper, I1PP2A antikoerper, LANP antikoerper, MAPM antikoerper, PHAP1 antikoerper, PHAPI antikoerper, PP32 antikoerper, Anp32 antikoerper, W91701 antikoerper, pp32 antikoerper, Anp32a antikoerper, CG5784 antikoerper, CT18148 antikoerper, CT42180 antikoerper, Dmel\\CG5784 antikoerper, anon-EST:fe3A2 antikoerper, wu:fj36e08 antikoerper, zgc:55516 antikoerper, ANP32D antikoerper, acidic nuclear phosphoprotein 32 family member A antikoerper, acidic (leucine-rich) nuclear phosphoprotein 32 family, member A antikoerper, CG5784 gene product from transcript CG5784-RB antikoerper, acidic nuclear phosphoprotein 32 family member A L homeolog antikoerper, ANP32A antikoerper, Anp32a antikoerper, Mapmodulin antikoerper, anp32a antikoerper, anp32a.L antikoerper

Hintergrund: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, C15orf1, LANP, Leucine-rich acidic nuclear protein, MAPM, Mapmodulin, PHAP1, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I

Gen-ID: 8125

UniProt: P39687