PDCD5 Antikörper (C-Term)

Produktnummer ABIN500463

Dieses Anti-PDCD5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PDCD5 in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PDCD5 Antikörper (C-Term) (ABIN500463)

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDCD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-PDCD5 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects PDCD5 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: PDCD5 antibody was raised against a 21 amino acid peptide from near the carboxy terminus of human PDCD5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PDCD5

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Andere Bezeichnung: PDCD5

Hintergrund: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5?-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.Synonyms: Programmed cell death protein 5, TF-1 cell apoptosis-related protein 19, TFAR19

Gen-ID: 9141

NCBI Accession: NP_004699

UniProt: O14737