CUL9 Antikörper (C-Term)

Produktnummer ABIN500449

Produktdetails anti-CUL9 Antikörper

Target: CUL9 (Cullin 9 (CUL9))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CUL9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Cullin-9.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Peptide affinity chromatography

Immunogen: PARC antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PARC.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immuncytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu CUL9

Target: CUL9 (Cullin 9 (CUL9))

Andere Bezeichnung: Cullin-9 (CUL9 Produkte)

Hintergrund: The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.Synonyms: CUL-9, H7AP1, KIAA0708, PARC, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein

Gen-ID: 23113

NCBI Accession: NP_055904

UniProt: Q8IWT3