Occludin Antikörper (C-Term)

Produktnummer ABIN500409

Dieser Anti-Occludin Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Occludin in WB, IF, IHC (p) und EIA. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für Occludin Antikörper (C-Term) (ABIN500409)

Target: Occludin (OCLN)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Occludin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Occludin Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detectc OCLN.

Aufreinigung: Peptide affinity chromatography

Immunogen: OCLN antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human OCLN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Occludin Antikörper (ABIN500409)

Ferguson, Kwak, Lim, Cesaire, Mills, Dalmage, Jones, Tarasov, Dyba, Robey, Yang, Simpson, Karim, Butcher, Gartrell, Gottesman, Jackson: "Angulin-1/LSR inhibition transiently disrupts the blood-tumor barrier to enhance doxil permeability and impair malignant glioma progression." in: bioRxiv : the preprint server for biology, (2025) (PubMed).

Liang, Zhang, Deng, He, Liang, Liang, Chen, Tang, Chen, Yang: "The Potential Effect of Chinese Herbal Formula Hongqijiangzhi Fang in Improving NAFLD: Focusing on NLRP3 Inflammasome and Gut Microbiota." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 5378961, (2018) (PubMed).

Zhang, Tang, Deng, Chen, Liang, Xie, He, Chen, Yang: "Effects of shenling baizhu powder herbal formula on intestinal microbiota in high-fat diet-induced NAFLD rats." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 1025-1036, (2018) (PubMed).

Details zu Occludin

Target: Occludin (OCLN)

Andere Bezeichnung: Occludin

Hintergrund: Tight junctions act as a semi-permeable barrier to the transport of ions, solutes, and water and are considered to function as a fence that divides apical and basolateral domains of plasma membranes. Tight junctions coordinate a variety of signaling and trafficking molecules regulating cell differentiation, proliferation, and polarity and contain a number of junctional proteins including Occludin, Claudins, junctional adhesion molecules (JAMs), as well as multiple scaffold proteins. Occludin, the first identified component of tight junction strands, is thought function as a signal transmitter in multiple signaling pathways and can associate with multiple kinases and phosphatases such as PI3-kinase and protein phosphatases 1 and 2A. At least two isoforms of OCLN are known to exist.Synonyms: OCLN

Gen-ID: 4950

UniProt: Q16625

Pathways: Cell-Cell Junction Organization, Hepatitis C