MOAP1 antikoerper, MAP-1 antikoerper, PNMA4 antikoerper, AA987038 antikoerper, Map-1 antikoerper, Pnma4 antikoerper, modulator of apoptosis 1 antikoerper, modulator of apoptosis 1 S homeolog antikoerper, MOAP1 antikoerper, moap1.S antikoerper, Moap1 antikoerper
Hintergrund
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo (4). It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis (5).Synonyms: MAP-1, MAP1, Modulator of apoptosis 1