MANF Antikörper (N-Term)

Produktnummer ABIN500226

Dieses Anti-MANF-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MANF in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MANF Antikörper (N-Term) (ABIN500226)

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MANF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-MANF Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects ARMET / ARP at N-term. It does not cross-react with CDNF.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chroomatography

Immunogen: MANF antibody was raised against a 12 amino acid peptide from near the amino terminus of human MANF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu MANF

Target: MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))

Andere Bezeichnung: ARMET / ARP

Hintergrund: MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.Synonyms: Arginine-rich protein, MANF, Mesencephalic astrocyte-derived neurotrophic factor

Gen-ID: 7873

UniProt: P55145