XPO5 Antikörper (AA 221-320) (AbBy Fluor® 680)

Produktnummer ABIN5002224

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch XPO5 in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für XPO5 Antikörper (AA 221-320) (AbBy Fluor® 680) (ABIN5002224)

Target: XPO5 (Exportin 5 (XPO5))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPO5 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-XPO5 Antikörper (AbBy Fluor® 680)

Bindungsspezifität: AA 221-320

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Exportin 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu XPO5

Target: XPO5 (Exportin 5 (XPO5))

Andere Bezeichnung: Exportin 5

Hintergrund:

Synonyms: Exp 5, Exp5, Exportin 5, Exportin-5, Exportin5, FLJ14239, FLJ32057, FLJ45606, KIAA1291, Ran binding protein 21, Ran-binding protein 21, Ranbp 21, Ranbp21, Xpo 5, xpo5, XPO5_HUMAN.

Background: Exportin 5 (XPO5) is a member of the importin _ family of proteins and functions in tRNA export in a sequence dependent fashion. More recently, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA processing occurs to produce mature miRNAs. Study of the miRNA biosynthesis pathway is essential in understanding the process of oncogenesis as global downregulation of miRNAs and the resulting alterations in the expression of tumor suppressor and oncogenic proteins is a common phenotype of cancers cells . Research studies have shown disruption of exportin 5 functions in many types of cancers including breast and lung, where pre-miRNA accumulates in the nucleus and miRNA maturation is impaired.

Pathways: Regulatorische RNA Pathways, Protein targeting to Nucleus