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RNF19A Antikörper (AA 621-720) (AbBy Fluor® 750)

Der Kaninchen Polyklonal Anti-RNF19A-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, RNF19A in Proben von Human zu detektieren.
Produktnummer ABIN5001463

Kurzübersicht für RNF19A Antikörper (AA 621-720) (AbBy Fluor® 750) (ABIN5001463)

Target

Alle RNF19A Antikörper anzeigen
RNF19A (Ring Finger Protein 19A (RNF19A))

Reaktivität

  • 45
  • 7
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 43
  • 1
  • 1
Kaninchen

Klonalität

  • 44
  • 1
Polyklonal

Konjugat

  • 17
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser RNF19A Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation

  • 32
  • 22
  • 12
  • 12
  • 10
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 621-720

    Homologie

    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DORFIN/RNF19

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    RNF19A (Ring Finger Protein 19A (RNF19A))

    Andere Bezeichnung

    DORFIN/RNF19

    Hintergrund

    Synonyms: Dorfin, Double ring finger protein, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, p38, p38 protein, Ring finger protein 19, RING finger protein 19A, Ring IBR ring domain containing protein Dorfin, RN19A_HUMAN, RNF19, RNF19A, Ubce7ip2, UIP117, XYbp, AA032313, DKFZP566B1346.

    Background: Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson?s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.

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