FERMT3 Antikörper (C-Term)

Produktnummer ABIN500122

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FERMT3 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für FERMT3 Antikörper (C-Term) (ABIN500122)

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FERMT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-FERMT3 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects FERMT3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: KINDLIN3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu FERMT3

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Andere Bezeichnung: FERMT3

Hintergrund: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.Synonyms: Fermitin family homolog 3, KIND3, Kindlin-3, MIG2-like protein, MIG2B, URP2, Unc-112-related protein 2

Gen-ID: 83706

NCBI Accession: NP_848537

UniProt: Q86UX7