Junctophilin 3 Antikörper (C-Term)

Produktnummer ABIN500100

Dieses Anti-Junctophilin 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Junctophilin 3 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Junctophilin 3 Antikörper (C-Term) (ABIN500100)

Target: Junctophilin 3 (JPH3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Junctophilin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Junctophilin 3 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects JPH3 at C-term.

Aufreinigung: Peptide affinity chromatography

Immunogen: JPH3 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human JPH3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Junctophilin 3

Target: Junctophilin 3 (JPH3)

Andere Bezeichnung: Junctophilin-3 / JPH3

Hintergrund: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.Synonyms: JP3, Junctophilin type 3, TNRC22, Trinucleotide repeat-containing gene 22 protein

Gen-ID: 57338

NCBI Accession: NP_065706

UniProt: Q8WXH2