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IRGM Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IRGM in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN500068

Kurzübersicht für IRGM Antikörper (N-Term) (ABIN500068)

Target

Alle IRGM Antikörper anzeigen
IRGM (Immunity-Related GTPase Family, M (IRGM))

Reaktivität

Human, Maus, Ratte

Wirt

  • 33
  • 4
Kaninchen

Klonalität

  • 33
  • 4
Polyklonal

Konjugat

  • 12
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IRGM Antikörper ist unkonjugiert

Applikation

  • 30
  • 15
  • 13
  • 13
  • 7
  • 5
  • 3
  • 1
Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Spezifität

    This antibody detects IRGM at N-term.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, mouse, rat

    Aufreinigung

    Peptide affinity chromatography

    Immunogen

    IRGM antibody was raised against a 17 amino acid peptide near the amino terminus of the human IRGM.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target

    IRGM (Immunity-Related GTPase Family, M (IRGM))

    Andere Bezeichnung

    IRGM / LRG-47

    Hintergrund

    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47

    Gen-ID

    345611

    UniProt

    F8VPC9
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