IRGC Antikörper (C-Term)

Produktnummer ABIN500066

Der Kaninchen Polyklonal Anti-IRGC-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, IRGC in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für IRGC Antikörper (C-Term) (ABIN500066)

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRGC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-IRGC Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects IRGC at C-term. It will recognize both isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: IRGC antibody was raised against a 12 amino acid peptide near the carboxy terminus of human IRGC.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu IRGC

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Andere Bezeichnung: IRGC

Hintergrund: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist.Synonyms: Cinema 1, IIGP5, IRGC1, Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5

Gen-ID: 56269

NCBI Accession: NP_062558

UniProt: Q6NXR0