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ILP-2 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ILP-2 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN500020

Kurzübersicht für ILP-2 Antikörper (ABIN500020)

Target

Alle ILP-2 (BIRC8) Antikörper anzeigen
ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

Reaktivität

Human, Ratte, Maus

Wirt

  • 22
  • 2
Kaninchen

Klonalität

  • 24
Polyklonal

Konjugat

  • 10
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ILP-2 Antikörper ist unkonjugiert

Applikation

  • 13
  • 13
  • 8
  • 8
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • Spezifität

    ILP-2 antibody was raised with against a synthetic peptide corresponding to amino acids near the amino terminus of human ILP-2.

    Aufreinigung

    Affinity chromatography purified via peptide column

    Immunogen

    Human ILP-2 Peptide

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western Blot: 1 to 2 μg/mL. Human HepG2 or MOLT4 cell lysate can be used as a positivecontrol and a band at approximately 33 kDa can be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C.
  • Target

    ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

    Andere Bezeichnung

    BIRC8 / ILP2

    Hintergrund

    Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.Synonyms: Baculoviral IAP repeat-containing protein 8, IAP-like protein 2, ILP-2, Inhibitor of apoptosis-like protein 2, Testis-specific inhibitor of apoptosis

    Gen-ID

    112401

    NCBI Accession

    NP_203127

    UniProt

    Q96P09
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