INSM1 Antikörper (N-Term)

Produktnummer ABIN499952

Der Kaninchen Polyklonal Anti-INSM1-Antikörper wurde für WB und EIA validiert. Er ist geeignet, INSM1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für INSM1 Antikörper (N-Term) (ABIN499952)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-INSM1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to IA-1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: IA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Andere Bezeichnung: INSM1 / IA1

Hintergrund: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100 % of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.Synonyms: Insulinoma-associated protein 1, Zinc finger protein IA-1

Gen-ID: 3642

NCBI Accession: NP_002187

UniProt: Q01101