GSTP1 Antikörper (Center)

Produktnummer ABIN499938

Dieses Anti-GSTP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GSTP1 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für GSTP1 Antikörper (Center) (ABIN499938)

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSTP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GSTP1 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to GSTP1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: GSTP1 antibody was raised against a 14 amino acid peptide from near the center of human GSTP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu GSTP1

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Andere Bezeichnung: GSTP1 / GST3

Hintergrund: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer. More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson's disease. CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer.Synonyms: FAEES3, GST class-pi, GST pi, GSTP1-1, Glutathione S-transferase P

Gen-ID: 2950

NCBI Accession: NP_000843

UniProt: P09211

Pathways: Cellular Response to Molecule of Bacterial Origin