GRIK4 Antikörper (N-Term)

Produktnummer ABIN499930

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GRIK4 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für GRIK4 Antikörper (N-Term) (ABIN499930)

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GRIK4 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Grik4 antibody was raised against a 14 amino acid peptide near the amino terminus of the human Grik4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu GRIK4

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Andere Bezeichnung: Glutamate Receptor KA1 / GRIK4

Hintergrund: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.Synonyms: EAA1, Excitatory amino acid receptor 1, Glutamate receptor ionotropic kainate 4

Gen-ID: 2900

UniProt: Q16099

Pathways: Synaptic Membrane