GPR3 Antikörper (C-Term)

Produktnummer ABIN499914

Dieses Anti-GPR3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GPR3 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für GPR3 Antikörper (C-Term) (ABIN499914)

Target: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GPR3 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to GPR3.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: GPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu GPR3

Target: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Andere Bezeichnung: GPR3 / ACCA

Hintergrund: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3

Gen-ID: 2827

UniProt: P46089

Pathways: cAMP Metabolic Process