GPAM Antikörper (C-Term)

Produktnummer ABIN499910

Der Kaninchen Polyklonal anti-GPAM Antikörper wird verwendet zum Nachweis von GPAM in Proben von Human, Ratte und Maus. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für GPAM Antikörper (C-Term) (ABIN499910)

Target: GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GPAM Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to GPAT1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: GPAT1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPAT1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu GPAM

Target: GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial (GPAM))

Andere Bezeichnung: GPAM / GPAT1

Hintergrund: Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis, steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.Synonyms: Glycerol-3-phosphate acyltransferase 1, KIAA1560

Gen-ID: 57678

NCBI Accession: NP_065969

UniProt: Q9HCL2

Pathways: Activated T Cell Proliferation