FAM59A Antikörper (C-Term)

Produktnummer ABIN499824

Der Kaninchen Polyklonal anti-FAM59A Antikörper (ABIN499824) detektiert spezifisch FAM59A in WB, IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für FAM59A Antikörper (C-Term) (ABIN499824)

Target: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM59A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-FAM59A Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: FAM59A antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human FAM59A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu FAM59A

Target: FAM59A (Family with Sequence Similarity 59, Member A (FAM59A))

Andere Bezeichnung: FAM59A

Hintergrund: FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.Synonyms: C18orf11

Gen-ID: 64762

UniProt: Q9H706

Pathways: EGFR Signaling Pathway