FAIM Antikörper (C-Term)

Produktnummer ABIN499820

Der Kaninchen Polyklonal Anti-FAIM-Antikörper wurde für WB und EIA validiert. Er ist geeignet, FAIM in Proben von Human und Maus zu detektieren.

Kurzübersicht für FAIM Antikörper (C-Term) (ABIN499820)

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAIM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-FAIM Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to FAIM.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: FAIM antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human FAIM.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu FAIM

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Andere Bezeichnung: FAIM

Hintergrund: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappaB and the Ras-ERK pathway.Synonyms: FAIM-1, FAIM1, Fas Apoptotic Inhibitory Molecule 1

Gen-ID: 55179

NCBI Accession: NP_060617

UniProt: Q9NVQ4