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TMC8 Antikörper (Center)

Dieses Rabbit Polyclonal-Antikörper erkennt spezifisch TMC8 in WB, IHC (p), EIA. Er zeigt eine Reaktivität gegenüber Human, Mouse, Rat.
Produktnummer ABIN499810

Kurzübersicht für TMC8 Antikörper (Center) (ABIN499810)

Target

Alle TMC8 Antikörper anzeigen
TMC8 (Transmembrane Channel-Like 8 (TMC8))

Reaktivität

Human, Maus, Ratte

Wirt

  • 30
Kaninchen

Klonalität

  • 30
Polyklonal

Konjugat

  • 11
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TMC8 Antikörper ist unkonjugiert

Applikation

  • 29
  • 15
  • 13
  • 13
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Center

    Spezifität

    This antibody reacts to EVER2.

    Aufreinigung

    Affinity chromatography purified via peptide column

    Immunogen

    EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C.
  • Target

    TMC8 (Transmembrane Channel-Like 8 (TMC8))

    Andere Bezeichnung

    TMC8

    Hintergrund

    Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8

    Gen-ID

    147138

    UniProt

    Q8IU68
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