TMC6 Antikörper (N-Term)

Produktnummer ABIN499806

Dieses Anti-TMC6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TMC6 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TMC6 Antikörper (N-Term) (ABIN499806)

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-TMC6 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to EVER1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: EVER1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human EVER1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Andere Bezeichnung: TMC6 / EVER1

Hintergrund: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.Synonyms: EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4, Transmembrane channel-like protein 6

Gen-ID: 11322

UniProt: Q7Z403