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HMG20B Antikörper (AA 1-100) (AbBy Fluor® 750)

This anti-HMG20B antibody (ABIN4997589) is a Rabbit Polyclonal antibody detecting HMG20B in WB, IF (cc), IF (p). Suitable for Mouse.
Produktnummer ABIN4997589

Quick Overview for HMG20B Antikörper (AA 1-100) (AbBy Fluor® 750) (ABIN4997589)

Target

Alle HMG20B Antikörper anzeigen
HMG20B (High Mobility Group 20B (HMG20B))

Reaktivität

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  • 26
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  • 5
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  • 4
  • 2
  • 1
  • 1
  • 1
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Maus

Wirt

  • 53
  • 2
Kaninchen

Klonalität

  • 54
  • 1
Polyklonal

Konjugat

  • 35
  • 2
  • 1
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  • 1
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  • 1
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  • 1
  • 1
  • 1
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  • 1
  • 1
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  • 1
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  • 1
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Dieser HMG20B Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation

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  • 12
  • 9
  • 8
  • 6
  • 4
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
    AA 1-100

    Kreuzreaktivität

    Maus

    Homologie

    Human,Rat,Cow

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human BRAF35

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    HMG20B (High Mobility Group 20B (HMG20B))

    Andere Bezeichnung

    BRAF35

    Hintergrund

    Synonyms: BRAF25, BRAF35, BRCA 2 Associated Factor 35 kDa, BRCA2 associated factor 35, BRCA2-associated factor 35, High Mobility Group Protein 20B, HM20B_HUMAN, HMG 20B, HMG box containing protein 20B, HMG box-containing protein 20B, HMG domain-containing protein 2, HMG domain-containing protein HMGX2, hmg20b, HMGX2, PP7706, pp8857, SMARCE1 related protein, SMARCE1-related protein, SMARCE1r, sox like, Sox like transcriptional factor, Sox-like transcriptional factor, SOXL, Structural DNA binding protein BRAF35, Structural DNA-binding protein BRAF35, SWI/SNF related, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily E member 1 related, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related.

    Background: The breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45 % of families with high incidence of breast cancer and at least 80 % of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35/BRCA2 complex in cell cycle regulation.

    Gen-ID

    10362
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