DNAL1 Antikörper (C-Term)

Produktnummer ABIN499752

Dieses Anti-DNAL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DNAL1 in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für DNAL1 Antikörper (C-Term) (ABIN499752)

Target: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-DNAL1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts top DNAL1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: DNAL1 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human DNAL1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu DNAL1

Target: DNAL1 (Dynein, Axonemal, Light Chain 1 (DNAL1))

Andere Bezeichnung: DNAL1

Hintergrund: DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.Synonyms: C14orf168, Dynein light chain 1 axonemal

Gen-ID: 83544

NCBI Accession: NP_113615

UniProt: Q4LDG9