DISC1 Antikörper (Center)

Produktnummer ABIN499748

Der Kaninchen Polyklonal anti-DISC1 Antikörper wird verwendet zum Nachweis von DISC1 in Proben von Human und Maus. Er wurde validiert für WB, IF und EIA.

Kurzübersicht für DISC1 Antikörper (Center) (ABIN499748)

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-DISC1 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to DISC1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: DISC1 antibody was raised against a 18 amino acid peptide from near the center of human DISC1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Andere Bezeichnung: DISC1

Hintergrund: Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3e from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.Synonyms: DISC-1, Disrupted in schizophrenia 1 protein, KIAA0457

Gen-ID: 27185

NCBI Accession: NP_061132

UniProt: Q9NRI5

Pathways: Regulation of Cell Size