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BIN2 Antikörper (AbBy Fluor® 680)

This anti-BIN2 antibody (ABIN4997474) is a Rabbit Polyclonal antibody detecting BIN2 in WB, IF (p). Suitable for Human, Rat, Mouse.
Produktnummer ABIN4997474

Kurzübersicht für BIN2 Antikörper (AbBy Fluor® 680) (ABIN4997474)

Target

Alle BIN2 Antikörper anzeigen
BIN2 (Bridging Integrator 2 (BIN2))

Reaktivität

  • 40
  • 15
  • 14
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 38
  • 2
Kaninchen

Klonalität

  • 38
  • 2
Polyklonal

Konjugat

  • 18
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BIN2 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 35
  • 16
  • 14
  • 12
  • 9
  • 5
  • 5
  • 5
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human BIN2/BRAP1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    BIN2 (Bridging Integrator 2 (BIN2))

    Andere Bezeichnung

    BIN2

    Hintergrund

    Synonyms: BIN2, BIN2_HUMAN, BRAP 1, Breast cancer associated protein BRAP1, Breast cancer-associated protein 1, Bridging integrator 2.

    Background: BAR proteins are characterized by a common N-terminal BAR (bin, amphiphysin and Rvs161/167) domain and are recognized as adaptor proteins that are involved in many cellular processes. BIN1 and BIN2 are BAR proteins that share 61 % sequence similarity. BIN1 (Bridging integrator 1) is a ubiquitously expressed regulatory protein for synaptic vesicle endocytosis. BIN1 also interacts with the transcription factors c-Myc and MyoD, potentially functioning as a tumor suppressor. BIN2, also known as Breast cancer-associated protein 1, is a 565 amino acid protein that interacts with BIN1. In contrast to BIN1, BIN2 lacks tumor suppressor features as well as a c-Myc interacting region. BIN2 shows preferred expression in tissues of hematopoietic origin, with high levels found in spleen, thymus, colon, placenta, lymphoid and granulocytic cells. There are two isoforms of BIN2 that are produced as a result of alternative splicing events.

    Gen-ID

    51411
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