Ataxin 1 Antikörper (pSer775) (AbBy Fluor® 750)
Kurzübersicht für Ataxin 1 Antikörper (pSer775) (AbBy Fluor® 750) (ABIN4996940)
Target
Alle Ataxin 1 (ATXN1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pSer775
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Kreuzreaktivität
- Human, Maus, Ratte
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Homologie
- Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic phosphopeptide derived from human Ataxin 1 around the phosphorylation site of Ser776
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Isotyp
- IgG
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Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- Ataxin 1 (ATXN1)
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Andere Bezeichnung
- Ataxin 1
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Hintergrund
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Synonyms: Ataxin 1 phospho S776,p-Ataxin 1 phospho S776, ATX1, ATXN1, SCA1, Ataxin 1, Ataxin-1, Ataxin1, Spinocerebellar ataxia type 1, ATX1_HUMAN.
Background: Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
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Gen-ID
- 6310
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Pathways
- Synaptic Membrane
Target
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