CUEDC2 Antikörper (C-Term)

Produktnummer ABIN499688

Der Kaninchen Polyklonal Anti-CUEDC2-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, CUEDC2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CUEDC2 Antikörper (C-Term) (ABIN499688)

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CUEDC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CUEDC2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to CUEDC2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CUEDC2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CUEDC2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CUEDC2 antibody can be used for detection of CUEDC2 at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CUEDC2

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Andere Bezeichnung: CUEDC2

Hintergrund: The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-a and IKK-b and decrease the activation of NF-kB by decreasing the activation of IKK. CUEDC2 antibody will not cross-react with CUEDC1.Synonyms: C10orf66, CUE domain-containing protein 2, HOYS6

Gen-ID: 79004

NCBI Accession: NP_076945

UniProt: Q9H467