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Apelin Antikörper (AA 65-77) (AbBy Fluor® 680)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Apelin in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN4996650

Kurzübersicht für Apelin Antikörper (AA 65-77) (AbBy Fluor® 680) (ABIN4996650)

Target

Alle Apelin (APLN) Antikörper anzeigen
Apelin (APLN)

Reaktivität

  • 64
  • 39
  • 34
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 70
  • 6
Kaninchen

Klonalität

  • 72
  • 4
Polyklonal

Konjugat

  • 41
  • 12
  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Apelin Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 51
  • 35
  • 24
  • 22
  • 21
  • 12
  • 12
  • 4
  • 4
  • 4
  • 4
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-77

    Spezifität

    The antibody's immunogen sequence is derived from the Apelin-13 peptide. Therefore the Antibody can detect each of the active peptides that can be produced via proteolytic processing of the Apelin precursor.

    Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Apelin

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Apelin (APLN)

    Andere Bezeichnung

    Apelin

    Hintergrund

    Synonyms: AGTRL1 ligand, APEL, APEL_HUMAN, Apelin-13, Apelin13, Apelin 13, APJ endogenous ligand, Apln, XNPEP2

    Background: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ, the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates, more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

    Gen-ID

    8862

    UniProt

    Q9ULZ1

    Pathways

    Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Feeding Behaviour
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