Claudin 1 Antikörper (C-Term)

Produktnummer ABIN499639

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Claudin 1 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für Claudin 1 Antikörper (C-Term) (ABIN499639)

Target: Claudin 1 (CLDN1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-Claudin 1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody recognizes CLDN1.

Aufreinigung: Peptide Affinity Chromatography

Immunogen: 20 amino acid peptide near the carboxyl terminus of Human CLDN1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CLDN1 antibody can be used for detection of CLDN1 at 1-2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Claudin 1

Target: Claudin 1 (CLDN1)

Andere Bezeichnung: Claudin-1 / CLDN1

Hintergrund: Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.Synonyms: CLD1, PRO944, SEMP1, Senescence-associated epithelial membrane protein, UNQ481

Gen-ID: 9076

UniProt: O95832

Pathways: Cell-Cell Junction Organization, Hepatitis C