CENPO Antikörper (Center)

Produktnummer ABIN499615

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CENPO in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für CENPO Antikörper (Center) (ABIN499615)

Target: CENPO (Centromere Protein O (CENPO))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-CENPO Antikörper

Bindungsspezifität: Center

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CENPO antibody was raised against a 16 amino acid peptide from near the center of human CENPO.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CENPO antibody can be used for detection of CENPO at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu CENPO

Target: CENPO (Centromere Protein O (CENPO))

Andere Bezeichnung: CENP-O

Hintergrund: Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.Synonyms: CENPO, Centromere protein O, ICEN36, Interphase centromere complex protein 36

Gen-ID: 79172

NCBI Accession: NP_077298

UniProt: Q9BU64