BST2 Antikörper (N-Term)

Produktnummer ABIN499505

Der Kaninchen Polyklonal Anti-BST2-Antikörper wurde für WB und EIA validiert. Er ist geeignet, BST2 in Proben von Human und Maus zu detektieren.

Kurzübersicht für BST2 Antikörper (N-Term) (ABIN499505)

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BST2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-BST2 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to Bst2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Bst2 antibody was raised against a 18 amino acid peptide near the amino terminus of the mouse Bst2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Bst2 antibody can be used for detection of Bst2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Andere Bezeichnung: CD317 / BST2

Hintergrund: Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

Gen-ID: 69550

UniProt: Q8R2Q8

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response