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BIK Antikörper (N-Term)

BIK Reaktivität: Human, Maus WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499467
  • Target Alle BIK Antikörper anzeigen
    BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))
    Bindungsspezifität
    • 18
    • 16
    • 8
    • 8
    • 7
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 75
    • 16
    • 3
    • 1
    Human, Maus
    Wirt
    • 73
    • 2
    Kaninchen
    Klonalität
    • 73
    • 2
    Polyklonal
    Konjugat
    • 32
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BIK Antikörper ist unkonjugiert
    Applikation
    • 57
    • 32
    • 32
    • 18
    • 14
    • 14
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This anitbody reacts to BIK.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    BIK antibody was raised against a 15 amino acid peptide from near the amino terminus of human BIK.
    Isotyp
    IgG
    Top Product
    Discover our top product BIK Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: BIK antibody can be used for the detection of BIK ot at 1 - 2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))
    Andere Bezeichnung
    BIK (BIK Produkte)
    Synonyme
    BIK antikoerper, Biklk antikoerper, Blk antikoerper, Nbk antikoerper, BIP1 antikoerper, BP4 antikoerper, NBK antikoerper, si:dkey-31f5.6 antikoerper, BCL2 interacting killer antikoerper, BCL2-interacting killer antikoerper, BCL2-interacting killer (apoptosis-inducing) antikoerper, BIK antikoerper, Bik antikoerper, bik antikoerper
    Hintergrund
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b(5) resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.Synonyms: Apoptosis inducer NBK, BIP1, BP4, Bcl-2-interacting killer, NBK
    Gen-ID
    638
    UniProt
    Q13323
    Pathways
    Positive Regulation of Endopeptidase Activity
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