BCL2L13 Antikörper (Intermediate Domain)

Produktnummer ABIN499433

Der Kaninchen Polyklonal Anti-BCL2L13-Antikörper wurde für WB, EIA und IHC (p) validiert. Er ist geeignet, BCL2L13 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für BCL2L13 Antikörper (Intermediate Domain) (ABIN499433)

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2L13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BCL2L13 Antikörper

Bindungsspezifität: Intermediate Domain

Spezifität: Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Human Bcl-rambo / Bcl-2 like protein 13 / Mil1 (Intermediate Domain) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Bcl-rambo antibody can be used for the detection of Bcl-rambo at 2 μg/mL. K562 cell lysate can be used as positive control. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BCL2L13

Target: BCL2L13 (BCL2-Like 13 (Apoptosis Facilitator) (BCL2L13))

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).Synonyms: BCL2L13, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, MIL1

Gen-ID: 23786

UniProt: Q9BXK5

Pathways: Positive Regulation of Endopeptidase Activity